This course aims to empower students with knowledge, orientations, and skills to evaluate pressing sustainability challenges and design entrepreneurial solutions that advance sustainability and deliver lasting positive change. Through case studies, frameworks, and hands-on projects, students learn about the entrepreneurial ecosystem of start-ups and venture capital, nonprofits and philanthropy, and other business models that can achieve co-benefits and sustainable outcomes. Students delve into the entrepreneurial founding and fundraising process and utilize a holistic integrative design approach to examine systems, engage stakeholders, and ultimately develop business models with the goal of delivering scalable and sustainable positive impact. The course combines lectures, videos, readings, guest speakers, discussion sessions, and group project-based learning. Students work in small teams to examine and engage in designing, prototyping, testing, and iterating on specific solutions, interventions, and business model innovations. The course culminates in a group project and final presentation prepared collaboratively by each team.